EXPLORE THE SCIENCE OF NUTRITION AND LONGEVITY WITH JAAN
At JAAN, we place special emphasis on the role of mitochondria — the body’s energy powerhouses — in healthy aging. Mitochondria are central not only to ATP production but also to signaling pathways that regulate apoptosis, inflammation, and cellular repair. With aging, mitochondrial dysfunction contributes to increased oxidative stress, impaired autophagy, and reduced metabolic flexibility — hallmarks of age‑related decline.
Our research focuses on how targeted nutrients, microbiome‑derived metabolites, and advanced dietary strategies can enhance mitochondrial biogenesis, activate AMPK and SIRT1 pathways, restore NAD⁺ metabolism, and support autophagy and redox balance. By fostering collaboration among clinicians, nutrition scientists, and microbiome researchers, JAAN is advancing a systems‑biology approach to longevity, where mitochondrial health is positioned as a cornerstone for extending both lifespan and health span.
WHY DO JAPANESE HAVE LONGER LIFESPAN
Discover the Power of Nutrition and Microbiota with JAAN.
Discover the Power of Mitochondria, Nutrition, and Microbiota with JAAN. Japan has one of the highest life expectancies in the world — and a key factor lies in how traditional diets rich in fermented foods support mitochondrial health. Fermentation produces a vast array of metabolites that not only nourish the gut microbiota but also influence mitochondrial function throughout the body. Healthy mitochondria are essential for sustained energy production, metabolic flexibility, immune resilience, and protection against age‑related decline. At JAAN, we explore how this synergy between nutrition, microbiota, and mitochondrial function forms the biological foundation for Japan’s remarkable longevity — and how these insights can be applied globally to extend both lifespan and health span.
NUTRITION & THE GUT - THE KEY TO VITALITY
Recent advances in longevity science highlight the central role of mitochondria in sustaining health and vitality. These organelles not only generate the ATP required for every cellular function but also regulate signaling pathways for autophagy, redox balance, and immune defense. With aging, mitochondrial efficiency declines, contributing to fatigue, inflammation, and increased risk of chronic disease.
Nutrition plays a decisive role: bioactive compounds from fermented foods, polyphenols, and microbiome‑derived metabolites can enhance mitochondrial biogenesis, restore NAD⁺ metabolism, and activate protective pathways such as AMPK and SIRT1. Optimizing mitochondrial function through targeted nutrition is emerging as a foundational strategy for extending healthspan and preventing age‑related decline.
At JAAN, we promote research at the intersection of nutrition and mitochondrial health, providing a scientific basis for strategies that support cellular vitality and longevity.